Jerome : (Verse 3) The help from Ephraim will cease, and the kingdom from Damascus, and the remnant of Syria will be like the glory of the children of Israel, declares the Lord of hosts. Then the help of God will cease from Ephraim, who in this place are understood as the Scribes and Pharisees, according to the prophecy of Hosea, who calls them adversaries of the people of God and names them Ephraim (Hosea 5 and 8). And the kingdom shall cease from Damascus, so that sin shall by no means reign, and the prince of sin, the devil, shall reign in Damascus, which once loved bloodshed; but the remnant of Syria, that is, those from the Gentiles who have believed, shall be as the sons of Israel were before, the kingdom of God being taken away from them and given to the Gentiles, who bear its fruit, as the Lord God of hosts has spoken through all His prophets. — Commentary on Isaiah