Lift up your hands in the sanctuary,.... Which Aben Ezra interprets of the priests lifting up their hands to bless the people; but Kimchi, better, of lifting up of the hands to God in prayer; see Psa 141:2; which should be done "with holiness", as the Targum renders it, in a holy manner; and is the same with lifting up holy hands, Ti1 2:8; or towards the holy place; the oracle in the holy of holies, and the ark of the covenant, typical of Christ; see Kg1 8:29, Psa 28:2; so Kimchi; or rather, according to Arama, unto the holy name of God, to whom prayer is to be directed; and bless the Lord; which is repeated, to show the importance of the work, that it might not be forgotten and neglected; this being a principal part of spiritual service, and greatly acceptable to God.