Isa. xlviii. 16.  Mr. C. F. Johnston remarks:  “In Isaiah xlviii. 16 St. Didymus, as translated by St. Jerome, gives Spiritum suum.  The Targum has the same.  St. Ambrose writes:  ‘Quis est qui dicit; misit me Dominus Deus et Spiritus Ejus; nisi Qui venit a Patre, ut salvos faceret peccatores?  Quem ut audis, et Spiritus misit; ne cum legis quia Filius Spiritum mittit, inferioris esse Spiritum crederes potestatis,’ (De Sp. S. iii. 1, § 7.)  The passage is quoted by St. Athanasius, St. Basil, St. Cyril Hieros., and, as far as the editor is aware, without any comment which would help to determine their way of understanding the case of τὸ πνεῦμα; but Origen, on the words ‘Whosoever shall humble himself as this little child’ (Comm. in Evang., Matt. xiii. 18) says,—quoting the original, which may be rendered, “‘humbling himself as this little child is imitating the Holy Spirit, who humbled Himself for men’s salvation.  That the Saviour and the Holy Ghost were sent by the Father for the salvation of men is made plain by Isaiah saying, in the person of the Saviour, ‘the Lord sent me, and His Spirit.’  It must be observed, however, that the phrase is ambiguous, for either God sent and the Holy Ghost also sent, the Saviour; or, as I understand, the Father sent both, the Saviour and the Holy Ghost.’”  The Vulgate and Beza both render “Spiritus.”  The order of the Hebrew is in favour of the nominative, as in the Vulgate and lxx.  cf. Note A on Chap. xlviii. of Isaiah in the Speaker’s Commentary.