For whosoever will save his life,.... See Gill on Mat 16:25. . Luke 9:25 luk 9:25 luk 9:25 luk 9:25For what is a man advantaged if he gain the whole world,.... Or what profit will it be unto him? all the honours, riches, and enjoyments of it will be of no use and service to him if he himself is lost: and lose himself; or his own soul; for he that loses his soul, which is his better and immortal part, loses himself: or be cast away: finally, and eternally, or "suffer loss" of eternal happiness and glory; that is, perishes, and is destroyed with an everlasting destruction; See Gill on Mat 16:26.