Jerome : (Verse 26, 27.) This is the plan that he has devised for the whole earth, and this is the hand that is stretched out over all the nations. For the Lord of hosts has purposed, and who can annul it? His hand is stretched out, and who can turn it back? For the whole earth has been interpreted as the entire world in the Septuagint, in the end of the oracle or vision against Babylon. What was hidden is revealed, that God has planned for the whole earth, that is, the world, and not just against the land of the Chaldeans and the king of Assyria and the Chaldeans: and his hand is stretched out or lifted up over all the nations, and not just over one nation, Babylon. From this it is shown that all the things that have been said pertain not specifically to one province, but generally to the whole world. And what is said, 'Who can weaken it, and who can turn it away?' should not be understood as difficult, as it is read, 'Who is wise and will understand these things?' (Psalms 106:43). And, 'Who do you think is the faithful and prudent steward?' (Luke 12:42), and similar things. But understood as impossible. For no one can thwart the plan of the Lord, nor can they turn away His outstretched or lofty hand from striking. — Commentary on Isaiah