Jerome : (Verse 21.) The seed of evildoers will not be called forever. Prepare his children for slaughter because of the iniquity of their fathers: they will not rise, nor will they inherit the land, nor will they fill the faces of the cities. All histories agree that after the killing of Balthasar, the grandson of Nebuchadnezzar, and the succession of Darius to the kingdom of the Chaldeans, no one from the offspring of Nebuchadnezzar ruled thereafter. Therefore, Scripture predicts that such devastation will come upon Babylon that no royal seed will remain, but because of the wickedness of the father, all offspring will be destroyed. But because we have moved to the final part of the sentence, the faces of the cities will not be filled up, it is written in Hebrew for cities, Arim (), which we can translate as adversaries; so the meaning is: no one from your seed will desire to restore the kingdom, an adversary will be raised up. According to the Seventy Interpreters, who said: Wicked seed, prepare your sons for destruction because of the sins of your father, I cannot understand the meaning. — Commentary on Isaiah Verecundus of Junca : God's warning is twofold, one directed toward the submissive and the other toward obstinate minds. As was said about the submissive: "I will punish their crimes with a rod and their sins with a whip, but I will not remove my mercy from them or deceive them in my truth." But the wrath of God's rebuke upon obstinate sinners is unbearable, as Isaiah testifies: "The descendants of the evil will never be named. Prepare their sons to be killed for the iniquity of their fathers. They will not rise, or inherit the earth or fill the face of the world with children. 'And I will rise against them,' says the Lord of hosts, 'and I will destroy the name of Babylon and its seed and offspring,' said the Lord." — COMMENTARY ON THE CANTICLE OF MANASSES 7:6