[This is the same as the theological distinction between substances and their modifications. “The former,” says Howe, “are the proper object of creation strictly taken; the modifications of things are not properly created, in the strictest sense of creation, but are educed and brought forth out of those substantial things that were themselves created, or made out of nothing.”—Germs are originated ex nihilo, and fall under creation proper; their evolution and development takes place according to the nature and inherent force of the germ, and falls under providence, in distinction from creation. See the writer’s Theological Essays, 133–137.—W.G.T.S.]