By the term “of whom” they wish to indicate the Creator; by the term “through whom,” the subordinate agent cf. Eunomius, Liber. Apol. § 27, where of the Son he says ὑπουργός. or instrument; On the word ὄργανον, a tool, as used of the Word of God, cf. Nestorius in Marius Merc. Migne, p. 761 & Cyr. Alex. Ep. 1.  Migne, x. 37.  “The creature did not give birth to the uncreated, but gave birth to man, organ of Godhead.”  cf. Thomasius, Christ. Dog. i. 336. Mr. Johnston quotes Philo (de Cher. § 35; i. 162. n.) as speaking of ὄργανον δὲ λόγον Θεοῦ δι᾽ οὗ κατεσκευάσθη (sc. ὁ κόσμος). by the term “in whom,” or “in which,” they mean to shew the time or place.  The object of all this is that the Creator of the universe Here of course the Son is meant. may be regarded as of no higher dignity than an instrument, and that the Holy Spirit may appear to be adding to existing things nothing more than the contribution derived from place or time.