Jerome : Verse 46. "And he cried out with a great voice: 'I am innocent of the blood of this woman...'" Because the Holy Spirit was roused up within him and dictated to the boy what he should say, his voice was great. And if there is any place in Holy Scripture where the voice of a sinner is called great, it has (yet) to be noted. — St. Jerome, Commentary on Daniel, CHAPTER THIRTEEN