Jerome : (Verse 22.) Woe to those who are mighty in drinking wine, and men of strength in mixing strong drink, that is, drunkenness. To those mentioned above who rise early in the morning to pursue drunkenness, and drink until evening, so that you burn with wine, he now also speaks of those who are mighty in drinking wine, and men of strength in mixing strong drink (Deuteronomy 32). Those who were intoxicated with the wine of dragons, and with the deadly venom of asps, they slandered with the power of the Lord. And they themselves, drunk, intoxicated the people, so that, like frenzied bacchantes, they shouted against the Lord. According to the tropology, we have already said: priests entering the Tabernacle of God should not drink wine and strong drink (Leviticus 10). We now add, that it is also commanded to the Nazarenes, who dedicate themselves to the Lord, that they should not drink wine or strong drink, or anything made from grapes, nor even eat dried grapes or vinegar made from wine (Numbers 6). But in Proverbs it is also commanded: Powerful men who are prone to anger; do not drink wine, lest when they drink, they forget wisdom. I think that there is an analogy between wine and drunkenness, in that wine is one disturbance out of many, for example, of lust, greed, gluttony, and envy. Drunkenness, on the other hand, contains within itself all the passions of vices, which we can more accurately call disturbances in the Latin language, because they overturn the state of the mind and make the drunkards unaware of what they are doing. Therefore, those who are in charge ought to be free from vices, especially anger, which is closest to madness, so that they may not harm their subjects even more as they gain more power. For someone who is full of drunkenness, he pretends to possess certain virtues by deceiving others and creating illusions. — Commentary on Isaiah