The Lord shall smite thee in the knees, and in the legs, with a sore botch, that cannot be healed,.... Which in those parts as it is very painful, so is not easily cured; and this which is threatened was incurable by the art of man, as others in Deu 28:27; and which should not stop there in the lower parts of the body, but proceed and spread: from the sole of thy foot unto the top of thy head; and so be filled with them, as Job was with his boils and ulcers.