Jerome : (Verse 16.) Lord, in distress they sought you, in tribulation they murmured your teaching. LXX: Lord, in tribulation I remembered you, in small tribulation your teaching was to us. For being indulgent, you have often been despised and not glorified; but on the contrary, all have departed from your knowledge; therefore, Lord, strike them, so that in distress they may seek you, and in tribulation may your teaching be to them: when such a weight of affliction rests upon them that they dare not even cry out confidently, but silently devour their sorrow. According to the Septuagint, in times of tribulation, the Prophet of the Lord remembers what is said in the psalm: In my distress I called upon the Lord, and he answered me and set me free (Psalms 117:5). And in another place: In my distress I called to the Lord, and he answered me (Psalms 120:1). Therefore, the Apostle speaks: We are afflicted in every way, but not crushed; perplexed, but not driven to despair (2 Corinthians 4:8). And in another place: For I consider that the sufferings of this present time are not worth comparing with the glory that is to be revealed to us (Romans 8:18). But if a small tribulation teaches, corrects, and reproves, how much more a great one, when we are reminded of our condition and the power of God! — Commentary on Isaiah