Therefore shall his calamity come suddenly,.... Unthought of and unexpected: he that deviseth mischief to others secretly shall have no warning of his own ruin, nor time and means of preventing it; the destruction of antichrist will be sudden, and of all wicked men at the coming of Christ, Th1 5:3; suddenly shall he be broken without remedy; or, "and there shall be no healing" (b): his bones will be broken to pieces, and there will be no cure for him; or he shall be like an earthen vessel, which, when broke, cannot be put together again. The ruin of wicked men is sudden, inevitable, and irreparable; so antichrist will "come to his end, and none shall help him", Dan 11:45. (b) "et non sanitas", Pagninus, Montanus; "curatio", Junius & Tremellius; "medicina", Piscator, Cocceius.