The letter against John of Jerusalem was written about the year 398 or 399, and was a product of the Origenistic controversy. Its immediate occasion was the visit of Epiphanius, bishop of Salamis in Cyprus, at Jerusalem, in 394. The bishop preached, in the Church of the Resurrection (§11), a pointed sermon against Origenism, which was thought to be so directly aimed at John that the latter sent his archdeacon to remonstrate with the preacher (§14). After many unseemly scenes, Epiphanius advised Jerome and his friends to separate from their bishop (§39). But how were they to have the ministrations of the Church? This difficulty was surmounted by Epiphanius, who took Jerome’s brother to the monastery which he had founded at Ad, in the diocese of Eleutheropolis, and there ordained him against his will, even using force to overcome his opposition (Jerome, Letter LI. 1). Epiphanius attempted to defend his action (Jerome, Letter LI. 2), but John, after some time, appealed to Alexandria against Jerome and his supporters as schismatics. The bishop, Theophilus, at once took the side of John: but a letter, written by his emissary Isidore and intended for John, fell into the hands of Jerome (§37). The letter showed that Isidore was coming as a mere partisan of John, and Jerome, therefore, treated both it and the bearer with secret contempt. The dispute was thus prolonged for about four years, and, after some attempts at reconciliation, and the exhibition of much bitterness, amounting to the practical excommunication of Jerome and his friends, the dispute was stopped, perhaps by Theophilus, perhaps through the influence of Melania. The letter written to Pammachius at Rome, in 397 or 398, against John, was abruptly broken off, and it is almost certain that it was never published during Jerome’s lifetime. Jerome afterwards had so much influence with Theophilus that we find him interceding for John, who had fallen under the Pontiff’s displeasure (Letter LXXXVI. 1).