The treatise is a letter to Pammachius, who had been disturbed by the complaints of Bishop John to Siricius, bishop of Rome, against Jerome. Jerome begins (1) by pleading necessity for his attack on the bishop. Epiphanius has accused him of heresy (2). Let him answer plainly (3), for it is pride alone (4) which prevents this. It is said that John’s letter of explanation or apology was approved by Theophilus (5); but it did not touch the point, that is, the accusation of Origenism. Only three points are treated (6), and Epiphanius adduced eight—namely (7) Origen’s opinions (i.) that the Son does not see the Father; (ii.) that souls are confined in earthly bodies, as in a prison; (iii.) that the devil may be saved; (iv.) that the skins with which God clothed Adam and Eve were human bodies; (v.) that the body in the resurrection will be without sex; (vi.) that the descriptions of Paradise are allegorical: trees meaning angels, and rivers the heavenly virtues; (vii) that the waters above and below the firmament are angels and devils; (viii.) that the image of God was altogether lost at the Fall. John, instead of answering on the first head, merely expressed his faith in the Trinity (8, 9), and all through tries to make out (10) that the question between him and Epiphanius relates merely to the ordination of Paulinianus. Jerome then relates the extraordinary scenes of the altercation between Epiphanius and John (11–14). He then turns to the Origenistic notions that angels are cast down into human souls (15, 16), that the spirits of men pass into the heavenly bodies (17) and that the souls of men had a previous existence (18), and pass up and down in the scale of creation (19, 20). John, instead of answering on these points, contents himself with protesting against Manichæism (21.) Jerome presses him on the question of the origin of souls (22), pronouncing rashly for creationism. He then passes to the question of the state of the body after the resurrection (23), asserting the restoration of the flesh as it now is (24–27), both in the case of Christ (28) and in our own, adducing testimonies from the Old Testament (29–32), and discussing the appearances of our Lord after His resurrection (34–36). He then passes to a detailed examination of John’s letter or “Apology” to Theophilus (37), quoting its words, and telling the story of the mission of Isidore (37, 38), and the attempts of the Count Archelaus to make peace (39). The ordination of Paulinianus, on which John lays stress, is a subterfuge (40, 41). The schism is due to the heretical tendencies of the bishop, who is everywhere denounced by Epiphanius (42, 43).