And he answered and said unto them,.... Not to his mother and brethren, but to those that told him of them, who either designed to reproach him with them, by reason of the meanness of them, or to interrupt him in his work: my mother and my brethren are these; pointing to his disciples: which hear the word of God; which he had been preaching, and was meant by the seed in the preceding parable: and do it; behave in their lives and conversations agreeably to it; and observe the precepts and ordinances in it; elsewhere called the will of God his Father; See Gill on Mat 12:49. See Gill on Mat 12:50.