Revelation 16:10 Revelation 16:10 And the fifth angel poured out his vial upon the seat of the beast; and his kingdom was full of darkness; and they gnawed their tongues for pain, By the seat, or throne of the beast, we are to understand the place where the beast hath his chief residence, and where his highest court is kept, and where his holiness’ s chair is set, in which the Pope sitteth as the infallible judge; that is, the city of Rome; for there his throne is placed, and his great power, and authority is principally exercised. The effects of this vial or plague are four, first, His kingdom was full of darkness: That is, the beast’ s kingdom and dominion, both political and ecclesiastical was greatly eclipsed and clouded. The ruin of Rome will exceedingly darken the grandeur, glory and pomp of the beast. Secondly, And they gnawed their tongues for pain: That is, they that worshipped the beast, or his image, or received his mark; namely, his kings, his cardinals, etc., were tormented and pained with grief, and sorrow, and sores, when they saw that great city burned and utterly destroyed by the righteous judgments of God. \