Athanasius of Alexandria : There can be no doubt that in refusing the accompaniment of an angel Moses was inviting God to lead them himself. God was making this promise, "This word that you have just spoken I shall accomplish, since you have found favor with me and I know you in preference to all the others." It is also said in Isaiah, "the one who made the shepherd of the sheep to ascend the earth? Where is he who put the Holy Spirit in their midst, who led Moses by his right hand?" … At that time God promised to lead the people himself, and now he promises to send, no longer an angel but the Spirit who is above the angels. It is he who becomes the guide of the people. He thereby shows that the Spirit is neither from among the creatures nor even an angel, but he is superior to creation, united to the divinity of the Father. — LETTER TO SERAPION 1:12 Cyril of Alexandria : Where is he who put in them the Holy Spirit, that is, he who established the divine and saving Spirit in them? For the Spirit descended from the Lord and guided them, saying, "David divinely uttered, 'Send forth your word and heal us.' " For the Lord is the Spirit; he works through the Spirit that is of the same nature. Where then is he? For they forgot him and did not seek him, when they clearly should have remembered him and loved him. Where is he who led Moses by the right hand? Moses was great, famous and lofty in dignity. And this is shown in that it says [Moses] led them, working through [the Spirit] who is the right hand of God. — COMMENTARY ON Isaiah 5:5. 63:11-14 Cyril of Alexandria : Indeed just as the Lord and the Son are one, the Lord is the Father. For they come together, and the Holy Spirit both is and can be understood to be in both, and he makes sharp the straight way of truth whenever the mind of believers lacks correct thinking. On account of this being the case, the Spirit is Lord and God, as the Scriptures declare, with the great Isaiah speaking concerning the race of Israel, "The Spirit came down from the Lord and led them." — ON THE HOLY AND CONSUBSTANTIAL TRINITY 7 Cyril of Alexandria : It seems that Isaiah is making mention here of the resurrection of Christ, the Savior of us all. "He who has gone up" is said in place of "he who has risen"—from the earth—the chief shepherd of all, not just that he was rising up from the dead, but in the sense that he was clearly distinct among human beings. For he became like one of us, undergoing birth from a woman according to the flesh—he who was the only-begotten Word of the Father. — COMMENTARY ON Isaiah 5:5.63:11-14 Theodoret of Cyrus : Just as with Pharaoh and the Egyptians chasing them, the people led by Moses crossed the sea, so, too, as the devil and the demons were waging war, Christ the master shattered the gates of death, was first to go through them and took with him human nature in its entirety! — COMMENTARY ON Isaiah 20:63.11-12