Arise, O Lord,.... To the destruction of thine enemies, and the salvation of thy people; See Gill on Psa 7:6; let not man prevail; the man of sin, antichrist, that is, let him not always prevail; he is the little horn that was to prevail against the saints, and has prevailed, Dan 7:21; but he shall not always prevail; this petition will be heard and answered; for though he shall cast down many thousands, he shall not be "strengthened" by it, Dan 11:12; where the same word is used as here; the Lamb at last shall overcome him and his ten kings, his supporters, and all that shall aid and assist him, Rev 17:14; let the Heathen be judged in thy sight; that is, the antichristian nations that adhere to the man of sin, let them be judged and punished in the sight of God, the Judge of all the earth, whose eyes are as a flame of fire; compare with this Joe 3:12.