And by these three was the third part of men killed,.... The Alexandrian copy, and some others, the Complutensian edition, the Vulgate Latin, Syriac, and Ethiopic versions, read, "by these three plagues": as the western Roman empire is in the preceding chapter frequently expressed by the third part of several things, see Rev 8:7; so here the eastern Roman empire by the third part of men; vast numbers of the inhabitants of which were destroyed by the Turks, through the use of guns, out of which issued fire, smoke, and brimstone; and Constantinople, the metropolis of it, was taken in this way, as before observed, with the taking of which the empire ceased. By the fire, and by the smoke, and by the brimstone, which issued out of their mouths; that is, by the firing of guns.