The integrity of the upright shall guide them,.... The Spirit of God is the best guide of an upright man; he leads into all truth, and unto the land of uprightness, and continues to be a guide, even unto death; and it is right to walk after him, and not after the flesh: and besides him, the upright man has the word of God as a lamp to his feet, and a light to his paths, which he does well to take heed to; and next to that is the sincerity and uprightness of his heart, which will not suffer him, knowingly and willingly, to go aside into crooked paths, or to do amiss: integrity of heart and innocency of hand go together; such are the followers of the Lamb, as described, Rev 14:4; see Psa 25:21; but the perverseness of transgressors shall destroy them; the perverse ways, words, and actions of such as transgress the law of God, deal treacherously with God and men, as the word (e) signifies, shall be their ruin: the perverse doctrines and worship of the man of sin, and his followers, shall bring destruction upon them, Th2 2:4. The word for "perverseness" is only used here and in Pro 15:4; and there plainly signifies the perverseness of the tongue or speech, and so may have respect to corrupt doctrine. (e) "perfidosorum", Junius & Tremellius, Piscator; "perfidorum", Cocceius, Michaelis.