Jerome : (Verse 17) All nations are as nothing before him, they are accounted by him as less than nothing and emptiness. LXX: All the nations are as nothing in his sight, and they are counted as worthless. But if all nations are in his sight as if they were not, and are considered as nothing and empty (though in all nations and in Israel also), therefore he himself is also as if he were not, and is considered as nothing and empty. We say this, so that his pride may be broken, and so that he may know that he is like the other nations. — Commentary on Isaiah Philoxenus of Mabbug : And the Prophet said, "He rebuketh the sea, and maketh it dry, and drieth up all the rivers;" and again, "He looketh on the earth and it trembleth; He rebuketh the mountains, and they smoke." And again the prophet Isaiah saith, "All the nations are accounted as nothing by Him." Now these things the Spirit of God spake concerning the power of God, that those things which were not He called to come into existence, and that what did exist He called and changed into nothing. To this power also He compareth faith. — 13 Ascetic Discourses, Discourse 2 -- On Faith