Be not wise in thine own eyes,.... So as to act independently of God; not to trust in him, nor acknowledge him, nor seek to him for help and direction; nor ask nor take the advice of others; but, being conceited and self-sufficient, lean to thine own understanding, as being wise enough to conduct all affairs in life by thy own discretion; and in matters of religion wiser than thy teachers, and even than the Scriptures, being wise above that which is written; pleasing thyself with thine own wisdom, as exceeding others; glorying in it as thine own acquisition, and not ascribing it to God, so far as it any ways deserves the name of wisdom; though for the most part that which men glory in, and are conceited of, is not wisdom, but folly; and at least it is their folly to boast of it and be elated with it; see Isa 5:21, Rom 12:16; fear the Lord; which is true wisdom; and, where this is not, there is none, let men be ever so conceited; and where this is there is humility; these two go together, and make a man wise, rich, and honourable, Pro 22:4. The fear of the Lord is opposed to pride, high-mindedness, and vain conceit, Rom 11:20; this includes reverence of God, faith in him, dependence on him, acknowledgment of him, seeking to him for direction, and carefulness not to offend him; and depart from evil; from the evil of self-confidence and self-conceit, and from all other evil; the fear of God influences men to avoid sin, and abstain from all appearance of it; by means and through the exercise of it men forsake it, and keep at a distance from it, Pro 16:6. Nehemiah could not do as others did, because of the fear of the Lord; and Job was a man that feared God, and therefore he avoided that which was evil, Neh 5:15.