Ambrose of Milan : By saying that he does not delight in the sacrifices of the people, God is saying this: I abound in my own [sacrifice], I do not seek yours, I do not desire whole burnt offerings of rams and the fat of lambs and the blood of bulls and of goats. And do not come so into my sight. — Interrogation of Job and David 4.9.33 Basil of Caesarea : How do you hope to find any redemption for your souls through sacrifices that are offered in quantity but with no repentance worth mentioning? For God is merciful not through the blood of animals or through slaughter on the altar but upon the contrite heart. For "the sacrifice to God is a contrite heart."It is fitting for the same to be said to those who are lavish in their expiations but do not repent through their deeds.… Scripture says, "What is the multitude of your sacrifices to me?" So it dismisses the multitude and seeks after the single sacrifice. — COMMENTARY ON Isaiah 1:24 Basil of Caesarea : Observe that God does not say that he does not wish for any blood, but for this particular blood from these particular animals. For he would not say that he does not wish for the blood that was poured out "in the last times for the annulment of sins," "which speaks more effectively than that of Abel," but he changes the sacrifices to the spiritual plane, since "the change of priesthood" is about to happen. For if he rejects the physical sacrifices, he manifestly rejects the high priest according to the law.… They of the stock of Aaron are cast out, therefore, so that he [Christ] according to the order of Melchizedek might enter instead. The "continuous sacrifices" are no more, no more the sacrifices of the Day of Atonement, no more "the ashes of the heifer which purify those that partake." For the sacrifice is one, the Christ, and the mortification of the saints according to him; the sprinkling is one, the bath of regeneration;14 the absolution of sins is one—the blood poured out for the salvation of the world. Because of this God renounces the former things, so that he may establish the latter. — COMMENTARY ON Isaiah 1:26 Jerome : (Verse 11) What use to me is the multitude of your sacrifices? says the Lord. I am full. I do not desire burnt sacrifices of rams, or the fat of fattened cattle, or the blood of bulls, or lambs, or goats. Because they exist, I did not desire them. The Septuagint translates 'I do not desire' as 'I will not desire', using the present tense instead of the past tense. Furthermore, according to the Hebrew, it demonstrates that God never desired the sacrifices of the Jews, as we read in the forty-ninth psalm: I will not accept a bull from your house, or goats from your flocks. For every beast of the forest is mine, the cattle on a thousand hills. I have known all the flying creatures of the sky, and the beauty of the field is with me. If I were hungry, I would not say to you: for the world is mine and all its fullness. Shall I eat the flesh of bulls, or drink the blood of goats? (Psalms 49, seq.) And when he rejected the ceremonies of the old Law, he passed on to the purity of the Gospel and showed what he desires for these things: Sacrifice to God the sacrifice of praise, and pay your vows to the Most High. Call upon me in the day of trouble, and I will deliver you, and you will honor me. Therefore, the content of this chapter, up to the point where it says: Judge the orphan, defend the widow, and come, let us reason together: it rejects sacrifices of victims and teaches that obedience to the Gospel is a superior sacrifice. And what he brings is to be understood in this sense: I am full, I need nothing: the earth is the Lord's and the fullness thereof (Psalms 24:1). Therefore, we have all received from his fullness. This can also be understood about those who, not obeying God's precepts, believe they can redeem themselves with gifts and offerings to God: or those who offer stolen goods and ill-gotten gains on the altar and to the poor. — Commentary on Isaiah