Remarkable enough it is that when, in the Council of Chalcedon, appeal was made to this third Canon, the Pope St. Leo declared that it had never been notified to Rome. As in the mean time it had taken effect throughout the whole East, as in this very council Nectarius, as soon as he is elected, presides instead of Timothy of Alexandria, it puts in a strong point of view the real self-government of the Eastern Church at this time; for the giving the Bishop of Constantinople precedence over Alexandria and Antioch was a proceeding which affected the whole Church, and so far altered its original order—one in which certainly the West might claim to have a voice. Tillemont goes on: “It would be very difficult to justify St. Leo, if he meant that the Roman Church had never known that the Bishop of Constantinople took the second place in the Church, and the first in the East, since his legates, whose conduct he entirely approves, had just themselves authorized it as a thing beyond dispute, and Eusebius of Dorylæum maintained that St. Leo himself had proved it.” The simple fact is, that, exceedingly unwilling as the Bishops of Rome were to sanction it, from this time, 381, to say the least, the Bishop of Constantinople appears uniformly as first bishop of the East.