Athanasius of Alexandria : It did not say, "He remedied our infirmities," lest, as being external to the body and only healing it, as he has always done, he should leave people subject still to death. Rather, he carries our infirmities, and he himself bears our sins, that it might be shown that he has become human for us, and that the body that in him bore them was his own body. — Discourses Against the Arians 3.31 Eusebius of Caesarea : Alone did he assume the penalties of our wicked deeds, not when we were half dead but even when already altogether foul and stinking in tombs and graves. — ECCLESIASTICAL HISTORY 10:4 Gregory the Dialogist : Kish, who is called harsh, signifies not only his elect, but also the Redeemer himself. For no one was harsher toward himself than he. For the prophet, indicating the severity of this harshness, says: "Truly he himself bore our infirmities, and he himself carried our sorrows" (Isa. 53:4). For to die is not to suffer for mortals, who are subject to the suffering of a condemned nature. He therefore was exceedingly harsh toward himself, who had nothing in himself by which he might suffer; but in order to free us by suffering, he graciously assumed that by which he might be harsh toward himself and be able to suffer. — SIX BOOKS ON 1 Kings 4:80 Jerome : But he was wounded for our transgressions, he was bruised for our iniquities: the chastisement of our peace was upon him, and with his stripes we are healed. LXX: But he was wounded for our sins, and he was weakened for our iniquities. He was wounded for our iniquities, saying in the psalm: They have dug my hands and my feet (Ps. XXI, 18), so that with his wound he might heal our wounds, and he was crushed, or afflicted because of our sins, so that he became a curse for us, to deliver us from the curse. For every man who hangs on a tree is cursed (Deut. XXI, Galat. III). Therefore, our discipline of peace is upon him. For what we should have endured for our own sins, He suffered for us, making peace through the blood of His cross, whether those on earth or those in heaven. For He Himself is our peace, who made both one, and broke down the middle wall of partition, abolishing in His flesh the enmity, that is, the law of commandments contained in ordinances, that He might create in Himself one new man, making peace. From which it is clear, that just as the bruised and lacerated body bears signs of injury in bruises and discoloration: so too the soul truly suffered for us, lest it be believed in Christ partly as truth and partly as falsehood (Rom. III). — Commentary on Isaiah