Therefore shall thou serve thine enemies, which the Lord shall send against thee,.... Since they would not serve the Lord their God, who was so good a master to them, and supplied them with all good things, and with plenty of them, they should serve other lords, their enemies, whom God would raise up and send against them; not only, the Assyrians, Chaldeans, and Babylonians, but the Romans, after described, whom they should find hard masters, and from whom they; should have very severe usage, and should be in hunger and in thirst, and in nakedness, and in want of all good things; being destitute of food, and drink and raiment, and the common necessaries of life, and so in famishing and starving circumstances: and he shall put a yoke of iron upon thy neck; bring them into a state of subjection to their enemies, which would be intolerable to them, and from which they would not be able to free themselves, any more than to break an iron yoke; which, as it agrees with the Babylonish captivity, and their subjection in that state, see Jer 28:13; so more especially with their bondage under the Romans, who are the legs of iron in Nebuchadnezzar's image, and the fourth beast with great iron teeth in Daniel's vision, Dan 2:33, and this yoke was to continue until he have destroyed thee; the Jews were under the Roman yoke, Roman governors being set over them, and Judea made a Roman province many years before the destruction of their nation, city, and temple, by them.