Jerome : (Verse 6) For the waters of Nemrim will be deserted. This town is on the Dead Sea, with salty waters, and even this itself is barren. Whether it alludes to the name, or whether it happened after the devastation, that even the waters turned bitter. Because the grass has withered, the bud has failed, all the greenness has perished. Not as some think, truly because the waters of Nemrim were barren, all the grass has dried up, but Scripture speaks metaphorically. And the meaning is, in all of Moab the waters of Nemrim will be salty and bitter; just as no grass sprouts there, so the whole province will suffer from drought, that is, from Segor to Oronaim, from borders to borders. The same thing is said by Jeremiah: The waters of Nemrim will be very bad (Jerem. XLVIII, 34). — Commentary on Isaiah Jerome : (Verse 6) And this will happen because the waters of Nemrim, that is, the teachings of heretics, which are compared to leopards and transgressors, will be deserted and brought to nothing. They are stubborn, whose variations and blemishes are not changed (Jeremiah XIII), and apostates, of whom we read in the Psalms, I have regarded all the sinners of the earth as transgressors (Psalm CXVIII, 119). Also, every plant and sprout, and everything that seemed green in their speech, withered. And they were visited by God according to the magnitude of their sins, so that those whom they had not felt through blessings, they would come to know through afflictions. — Commentary on Isaiah