Revelation 16:12 Revelation 16:12 And the sixth angel poured out his vial upon the great river Euphrates; and the water thereof was dried up, that the way of the kings of the east might be prepared. The object of God’ s wrath and plague poured out of this sixth vial is the great river Euphrates. There was a river which ran through Mesopotamia unto old Babylon, that by way of eminency is called the great river, the river Euphrates, \ unto which this river may bear some allusion. The principal benefits of a great river are three, first, revenue, \ Secondly, strength, \ Thirdly, riches, \ so of mystical Babylon. \ And the water thereof was dried up. By waters we may understand peoples, and multitudes, and nations, and tongues. \ By the drying up of the waters, we may understand the wasting and destroying of the Turk’ s dominion, kingdom and power, as the Turk’ s dominion was enlarged under the sixth trumpet, \ so it shall be wasted and destroyed by the pouring forth of the plagues of this sixth vial. That the way of the kings of the east might be prepared. By the kings of the east, we are to understand the Jews, whom God hath promised to bring from the east. \ They are called kings (as all the Lord’ s redeemed ones are,) \ for they shall have the first dominion. \ And kings of the east, because God hath promised to save them from the east country. \